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Judith Campisi | Targeting Senescent Cells to Alleviate Aging: A Simple Task?

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Judith Campisi | Targeting Senescent Cells to Alleviate Aging: A Simple Task?

At Ending Age-Related Diseases 2020, Prof. Judith Campisi of the Buck Institute for Research on Aging discussed the effects and usage of senolytics, drugs that remove senescent cells from the body. She went into the details of the stress and damage signals that cause cells to become senescent and the markers of senescent cells, noting that no marker is specific to senescence. She also discussed the senescence-associated secretory phenotype (SASP), which causes other cells to become senescent.

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Judith Campisi | Targeting Senescent Cells to Alleviate Aging: A Simple Task?

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  4. Wouldn't killing senescent cells cause the same problem as suppressing SASP ? If senescent cells are killed off, they're not secreting anymore and the 3 paths you mentioned are blocked again.

  5. do you think a combination of telomerase gene therapy and senolytic therapy, such as dasatinib and quercetin, can have an affect of prolonging healthspan in people who are already exercising and have healthy diet?

  6. Great talk, but it's the exact same talk she gave to another online conference. I guess this & that conference happened at the same time. I was hoping for some new glimmer of information.

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