Judith Campisi | Targeting Senescent Cells to Alleviate Aging: A Simple Task?
At Ending Age-Related Diseases 2020, Prof. Judith Campisi of the Buck Institute for Research on Aging discussed the effects and usage of senolytics, drugs that remove senescent cells from the body. She went into the details of the stress and damage signals that cause cells to become senescent and the markers of senescent cells, noting that no marker is specific to senescence. She also discussed the senescence-associated secretory phenotype (SASP), which causes other cells to become senescent.
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Judith Campisi | Targeting Senescent Cells to Alleviate Aging: A Simple Task?
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Wouldn't killing senescent cells cause the same problem as suppressing SASP ? If senescent cells are killed off, they're not secreting anymore and the 3 paths you mentioned are blocked again.
do you think a combination of telomerase gene therapy and senolytic therapy, such as dasatinib and quercetin, can have an affect of prolonging healthspan in people who are already exercising and have healthy diet?
not a fan she clearly doesnt think we can live forever or even barely extend lifespan
These phenomena are always more complicated than one might initially think
Terrific talk! Thank you — I have subscribed,
Great talk. I had no idea how complex the SASP was before this talk. Thanks so much for studying it in such great detail and thanks for participating in this conference!
Great talk, but it's the exact same talk she gave to another online conference. I guess this & that conference happened at the same time. I was hoping for some new glimmer of information.
Congratulations on 10,000 subscribers! Judy is one of the best!
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this is the kind of quality videos I expect from YouTube. Nicely explained
Judy is an awesome researcher!
Judy did a fantastic job in this video as always! Congrats to LEAF on 10k subs!